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Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription

Aziz Taghbalout, Chia-Hao Tung, Patricia A. Clow, Harianto Tjong, Ping Wang, Chee‐Hong Wong, Diane D. Mao, Rahul Maurya, Meng‐Fan Huang, Chew Yee Ngan, Albert H. Kim, Chia‐Lin Wei

2025Cancer Cell11 citationsDOIOpen Access PDF

Topics & Concepts

ChromatinEpigeneticsEnhancerBiologyCell biologyExtrachromosomal DNAGene silencingMechanism (biology)Transcription factorCancerTranscription (linguistics)Cancer cellDNAGeneticsCancer researchNucleoproteinOncogeneFunction (biology)DNA damageChromatin remodelingEpigenesisComputational biologyRegulation of gene expressionCell nucleusCellDNA methylationNuclear proteinNucleosomeEpigenomeDNA-binding proteinGenomics and Chromatin DynamicsCancer Genomics and DiagnosticsCRISPR and Genetic Engineering
Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription | Litcius