<i>IKZF1</i> alterations predict poor prognosis in adult and pediatric T-ALL
Mathieu Simonin, Ludovic Lhermitte, Marie-Émilie Dourthe, Étienne Lengliné, Carlos Graux, Nathalie Grardel, Jean‐Michel Cayuela, Isabelle Arnoux, Virginie Gandemer, Norbert Ifrah, Hervé Dombret, André Baruchel, Elizabeth Macintyre, Arnaud Petit, Nicolas Boissel, Vahid Asnafi
Abstract
Patient outcomes in T-cell acute lymphoblastic leukemia and lymphoblastic lymphoma (T-ALL/LBL) can be difficult to predict. Simonin et al report deletions and mutations in the gene encoding the transcription factor IKAROS among 1260 children and adults with immature T-ALL/LBL, defining its frequency and, importantly, its association with poor outcome in multivariate models. Pathogenic alterations in IKZF1 now can be added to minimal residual disease detection and the established 4-gene oncogenetic classifier to better predict poor outcomes of T-ALL/LBL.