Mitochondrial Reactive Oxygen Species Enhance Alveolar Macrophage Activity against Aspergillus fumigatus but Are Dispensable for Host Protection
Neta Shlezinger, Tobias M. Hohl
Abstract
neutralization is compensated by other killing mechanisms in the lung, demonstrating functional redundancy at the level of host defense in the respiratory tree. These findings have important implications for the development of host-directed therapies against invasive aspergillosis in susceptible patient populations.
Topics & Concepts
Aspergillus fumigatusBiologyMitochondrial ROSReactive oxygen speciesChronic granulomatous diseaseNADPH oxidaseMicrobiologyEffectorRespiratory burstCatalaseInnate immune systemMitochondrionAspergillosisAlternative oxidaseImmunologyCell biologyOxidative stressImmune systemBiochemistryNeutrophil, Myeloperoxidase and Oxidative MechanismsAntifungal resistance and susceptibilityFungal Infections and Studies