Retinoic acid promotes metabolic maturation of human Embryonic Stem Cell-derived Cardiomyocytes
Shumei Miao, Dandan Zhao, Xiaoxiao Wang, Xuan Ni, Xing Fang, Miao Yu, Lingqun Ye, Jingsi Yang, Hongchun Wu, Xinglong Han, Lina Qu, Lei Li, Feng Lan, Zhenya Shen, Wei Lei, Zhen‐Ao Zhao, Shijun Hu
Abstract
Our data indicated that RA treatment at an early time window (days 2-4) promotes the efficiency of cardiomyocyte differentiation and that RA treatment post beating (days 15-20) promotes cardiomyocyte maturation. The biphasic effects of RA provide new insights for improving cardiomyocyte differentiation and quality.
Topics & Concepts
Retinoic acidEmbryonic stem cellCell biologyStem cellCellBiologyChemistryCell cultureBiochemistryGeneticsGenePluripotent Stem Cells ResearchRNA Interference and Gene DeliveryNuclear Receptors and Signaling