MDK induces temozolomide resistance in glioblastoma by promoting cancer stem-like properties.
Xuehui Yu, Zhuan Zhou, Siyuan Tang, Kun Zhang, Xingzhi Peng, Peijun Zhou, Mingyu Zhang, Liangfang Shen, Lifang Yang
Abstract
, and the expression of MDK was positively correlated with Notch1, p-JNK and CD133. This study revealed that MDK induces TMZ resistance by improving the stem-like properties of GBM by upregulating the Notch1/p-JNK signaling pathway, which provides a possible target for therapeutic intervention of GBM, especially in TMZ-resistant GBM with high MDK expression.
Topics & Concepts
TemozolomideCancer researchGene knockdownGliomaGlioblastomaApoptosisDownregulation and upregulationMedicineChemistryGeneBiochemistryGlioma Diagnosis and TreatmentCancer Mechanisms and TherapyCancer-related Molecular Pathways