Construction of Thiazole-Fused Dihydropyrans via Formal [4 + 2] Cycloaddition Reaction on DNA
Wenting Wu, Zhen Sun, Xuan Wang, Xiaojie Lu, Dongcheng Dai
Abstract
An efficient and facile formal [4 + 2] cycloaddition reaction was developed to synthesize diverse thiazole-fused dihydropyrans (TFDP) on DNA. Mild reaction conditions, broad substrate scope, and compatibility with subsequent enzymatic ligation demonstrated the utility of this methodology in DNA-encoded library synthesis.
Topics & Concepts
CycloadditionChemistryThiazoleCombinatorial chemistryDNASubstrate (aquarium)Reaction conditionsStereochemistryCatalysisOrganic chemistryBiochemistryBiologyEcologyChemical Synthesis and AnalysisClick Chemistry and ApplicationsCarbohydrate Chemistry and Synthesis