MTP18 inhibition triggers mitochondrial hyperfusion to induce apoptosis through ROS-mediated lysosomal membrane permeabilization-dependent pathway in oral cancer
Debasna Pritimanjari Panigrahi, Srimanta Patra, Bishnu Prasad Behera, Pradyota Kumar Behera, Shankargouda Patil, Birija Sankar Patro, Laxmidhar Rout, Itisam Sarangi, Sujit K. Bhutia
Topics & Concepts
MitophagyCell biologyMitochondrial fissionApoptosisMitochondrionMFN1AutophagyCancer cellProgrammed cell deathmitochondrial fusionMitochondrial apoptosis-induced channelCytochrome cOxidative stressBiologyReactive oxygen speciesDNM1LChemistryMitochondrial DNACancerBiochemistryGeneticsGeneMitochondrial Function and PathologyAutophagy in Disease and TherapyUbiquitin and proteasome pathways