Metal-free alkylation of quinoxalinones with aryl alkyl ketones
Xinya Liu, Zhuangzhuang Guo, Yanpeng Liu, Xiaoyu Chen, Jingya Li, Dapeng Zou, Yangjie Wu, Yusheng Wu
Abstract
The first metal-free method for alkylation of quinoxalinones using cheap and stable aryl alkyl ketones as nucleophilic alkylation reagents is reported. This strategy greatly broadens the application channels of aryl alkyl ketones through carbon-carbon bond activation. In addition, the protocol has the advantages of simple operation, broad substrate scope, and good functional group tolerance.
Topics & Concepts
ChemistryAlkylationAlkylArylReagentNucleophileFunctional groupMetalSubstrate (aquarium)Organic chemistryCombinatorial chemistryCatalysisOceanographyPolymerGeologySynthesis and Biological EvaluationCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions