Transamidation of aromatic amines with formamides using cyclic dihydrogen tetrametaphosphate
Kishor Kumar Chouhan, Deep Chowdhury, Arup Mukherjee
Abstract
Amide fragments are found to be one of the key constituents in a wide range of natural products and pharmacologically active compounds. Herein, we report a simple and efficient procedure for transamidation with a cyclic dihydrogen tetrametaphosphate. The protocol is simple, does not require any additives, and encompasses a broad substrate scope. To comprehend the mechanism of the present methodology, detailed spectroscopic and kinetic studies were undertaken.
Topics & Concepts
ChemistryFormamidesAmideCombinatorial chemistrySubstrate (aquarium)Cyclic aminesOrganic chemistryComputational chemistryAmine gas treatingFormamideGeologyOceanographyChemical Synthesis and AnalysisSynthesis and Catalytic ReactionsAdvanced Synthetic Organic Chemistry