Advancements in chemical methodologies for the synthesis of 3-aroylimidazo[1,2-a]pyridines: an update of the decade
Ravi Rawat, Saurabh Verma
Abstract
Due to the wide range of applications in medicinal chemistry, imidazo[1,2-a]pyridines have attracted extensive interest in synthetic organic chemistry. It is recognized as a “drug prejudice,” as then great efforts have been directed toward the construction and functionalization of this privileged structure. Some of the prototypical functionalization’s, such as 3-aroylimidazo[1.2-a]pyridines were recognized for their application as therapeutics. The unsuccessful attempt of the popular acylation reaction, Friedel-Crafts acylation had disregarded the structure of 3-aroylimidazo[1,2-a]pyridine leaving a three-step long and exhausting procedure the only measure for its availability until now. However, in this decade strong efforts have been directed to develop different synthetic strategies to facilitate access to this privileged structure. Here, we present a systematic review based on different strategies employed for the synthesis of 3-aroylimidazo[1.2-a]pyridines, such as transition metal-catalyzed, multicomponent approach, metal supported on molecular sieves catalyzed, superparamagnetic nanoparticle catalyzed and metal-free approaches.