SPARC-positive macrophages are the superior prognostic factor in the microenvironment of diffuse large B-cell lymphoma and independent of MYC rearrangement and double-/triple-hit status
Giorgio Alberto Croci, Rex Au-Yeung, Sarah Reinke, Annette M. Staiger, Karoline Koch, Ilske Oschlies, Julia Richter, Viola Poeschel, Gerhard Held, Markus Loeffler, Lorenz Trümper, Andreas Rosenwald, German Ott, Rainer Spang, Bettina Altmann, Marita Ziepert, Wolfgang Hiddemann
Topics & Concepts
BCL6MedicineInternational Prognostic IndexDiffuse large B-cell lymphomaTumor microenvironmentImmunohistochemistryStromal cellCancer researchCD68LymphomaCD163PathologyProportional hazards modelOncologyInternal medicineB cellImmunologyPhenotypeBiologyGeneAntibodyGerminal centerTumor cellsBiochemistryLymphoma Diagnosis and TreatmentImmune cells in cancerCutaneous lymphoproliferative disorders research