Screening of Botanical Drugs against Lassa Virus Entry
Yang Liu, Jiao Guo, Junyuan Cao, Guangshun Zhang, Xiaoying Jia, Peilin Wang, Gengfu Xiao, Wei Wang
Abstract
Currently, there is no approved therapy to treat Lassa fever (LASF). Our goal was to identify potential candidate molecules for LASF therapy. Herein, we screened a botanical drug library and identified two compounds, casticin and bergamottin, that inhibited LASV entry via different mechanisms.
Topics & Concepts
Lassa virusArenavirusVirologyLassa feverBiologyViral entryLipid bilayer fusionEntry inhibitorLymphocytic choriomeningitisVirusViral replicationImmunologyAntigenCD8Viral Infections and Outbreaks ResearchHepatitis B Virus StudiesViral Infections and Vectors