Identification of natural product inhibitors of PTP1B based on high-throughput virtual screening strategy: In silico, in vitro and in vivo studies
Jifeng Zhao, Lihua Li, Xiaojing Guo, Haixia Zhang, Linlin Tang, Chuanhua Ding, Wen‐Shan Liu
Topics & Concepts
Virtual screeningBaicalinIn silicoIn vivoIn vitroPhosphorylationChemistryHigh-throughput screeningDocking (animal)BiochemistryProtein tyrosine phosphataseIC50PharmacologyDrug discoveryNatural productBiologyMedicineGeneHigh-performance liquid chromatographyBiotechnologyChromatographyNursingProtein Tyrosine PhosphatasesGlycosylation and Glycoproteins ResearchGalectins and Cancer Biology