Anti-HIV Tigliane Diterpenoids from <i>Wikstroemia scytophylla</i>
Kouharu Otsuki, Mi Zhang, Asuka Yamamoto, Minami Tsuji, Miyuko Tejima, Zisong Bai, Di Zhou, Li Huang, Chin‐Ho Chen, Kuo‐Hsiung Lee, Ning Li, Wei Li, Kazuo Koike
Abstract
During a chemical investigation of Wikstroemia scytophylla, three new [wikstrocins A–C (1–3)] and three known tigliane diterpenoids (4–6) were isolated. The structures of the new compounds were elucidated from extensive physiochemical and spectroscopic analysis. The correlations between the ECD Cotton effects and B ring structures of tiglianes were also evaluated. The isolated compounds were assessed for their anti-HIV activity against HIV-1 infection of MT4 cells, and two compounds (4 and 6) showed potent anti-HIV activity with IC50 values of 3.8 and 12.8 nM, respectively.
Topics & Concepts
StereochemistryHuman immunodeficiency virus (HIV)PharmacognosyTerpenoidTraditional medicineChemistryBiological activityBiologyMedicineIn vitroBiochemistryVirologyBioactive Natural Diterpenoids ResearchHymenoptera taxonomy and phylogenyBiological Activity of Diterpenoids and Biflavonoids