Controlled delivery of gold nanoparticle-coupled miRNA therapeutics<i>via</i>an injectable self-healing hydrogel
Casper F. T. van der Ven, Mark W. Tibbitt, João Conde, Alain van Mil, Jesper Hjortnaes, Pieter A. Doevendans, Joost P. G. Sluijter, Elena Aïkawa, Róbert Langer
Abstract
A novel injectable hydrogel drug delivery platform introduces miRNA therapeutics coupled to gold nanoparticles to cells in a 3D bioprinted heart valve disease model.
Topics & Concepts
Self-healingColloidal goldNanotechnologyNanoparticleSelf-healing hydrogelsMaterials scienceWound healingBiomedical engineeringMedicineSurgeryPolymer chemistryPathologyAlternative medicine3D Printing in Biomedical ResearchHydrogels: synthesis, properties, applicationsGraphene and Nanomaterials Applications