Naringin mitigates LPS-induced intestinal barrier injury in mice
Diaoyun Luo, Zhiqing Huang, Gang Jia, Hua Zhao, Guangmang Liu, Xiaoling Chen
Abstract
). However, the naringin treatment mitigated these effects induced by LPS. Taken together, our findings suggested that naringin attenuates LPS-induced intestinal barrier damage by inhibiting inflammatory factors and improving antioxidant function and intestinal tight junction, which might be mediated by activating the Nrf2 signaling and suppressing the TLR4/p38 MAPK/NF-κB signaling.
Topics & Concepts
NaringinChemistryPharmacologyBiologyChromatographyBarrier Structure and Function StudiesGinger and Zingiberaceae researchGut microbiota and health