The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
Yun‐Hee Youm, Kim Nguyen, Ryan W. Grant, Emily L. Goldberg, Monica Bodogai, Dongin Kim, Dominic P. D’Agostino, Noah J. Planavsky, Christopher Lupfer, Thirumala‐Devi Kanneganti, Seokwon Kang, Tamás L. Horváth, Tarek M. Fahmy, Peter A. Crawford, Arya Biragyn, Emad S. Alnemri, Vishwa Deep Dixit
Topics & Concepts
InflammasomeKetone bodiesNLRC4ChemistryButyrateAIM2BiochemistryGlycolysisCaspase 1MetabolismFermentationReceptorDiet and metabolism studiesInflammasome and immune disordersTryptophan and brain disorders