Synergistic alleviation effects of anchovy hydrolysates-catechin on scopolamine-induced mice memory deficits: the exploration of the potential relationship among gut-brain-axis
Tiantian Zhao, Chen Zhang, Saiyi Zhong, Qirong Chen, Shuo Liu, Wenjuan Jiao, Weifeng Liu, Lihua Huang, Yehui Zhang, Yousheng Zhang
Abstract
were altered. Notably, memory-related metabolites and neurotransmitters were significantly up-regulated by the administration of samples. Moreover, possible connections are observed among the gut microbiota, fecal metabolites, and brain neurotransmitters. Together, the regulation of the microbiota-metabolites-brain-neurotransmitters axis may be one of the mechanisms for APH-CA against scopolamine-induced cognitive deficits. In addition, the synergic effects of APH and CA were partially confirmed.
Topics & Concepts
Gut floraChemistryGut–brain axisPharmacologyCatechinBiologyBiochemistryAntioxidantPolyphenolTryptophan and brain disordersGut microbiota and healthNeuroinflammation and Neurodegeneration Mechanisms