Injectable shear-thinning polylysine hydrogels for localized immunotherapy of gastric cancer through repolarization of tumor-associated macrophages
Yang Yan, Yang Yang, Meili Chen, Jianquan Chen, Jinyan Wang, Yajun Ma, Hanqing Qian
Abstract
. The anti-tumor efficacy of PR-Gel in a subcutaneous xenograft model of gastric cancer showed that the hydrogels possess good tumor growth suppression properties after a single injection. Furthermore, an increased iNOS/CD206 ratio in TAMs and enhanced CD8+ T cell infiltration were also observed within the TME after the treatment with PR-Gel. Hence, the biocompatible, shear-thinning, injectable hydrogels are a promising noninvasive drug-delivery platform for the regulation of the immunosuppressive TME and have great potential in localized immunotherapy against gastric cancer.
Topics & Concepts
ImmunotherapyRepolarizationSelf-healing hydrogelsPolylysineCancer immunotherapyCancerChemistryCancer researchMedicineInternal medicineElectrophysiologyBiochemistryPolymer chemistryImmune cells in cancerCancer Cells and MetastasisImmune Cell Function and Interaction