An ultraconserved snoRNA-like element in long noncoding RNA CRNDE promotes ribosome biogenesis and cell proliferation
Jong-Sun Lee, Tu Dan, He Zhang, Yujing Cheng, Frederick Rehfeld, James Brugarolas, Joshua T. Mendell
Abstract
through a sequence element adjacent to the UCE. These findings highlight the functional versatility of snoRNA sequences and expand the known mechanisms through which noncoding RNAs orchestrate ribosome biogenesis.
Topics & Concepts
BiologySmall nucleolar RNABiogenesisLong non-coding RNARibosome biogenesisRibosomeCell biologyRNANon-coding RNACell growthComputational biologyGeneticsGeneCancer-related molecular mechanisms researchRNA modifications and cancerRNA and protein synthesis mechanisms