Reduced basal macrovascular and microvascular cerebral blood flow in young adults with metabolic syndrome: potential mechanisms
Katrina J. Carter, Aaron T. Ward, J. Mikhail Kellawan, John W. Harrell, Garrett L. Peltonen, Grant S. Roberts, Awni Al‐Subu, Scott Hagen, Ronald C. Serlin, Marlowe W. Eldridge, Oliver Wieben, William G. Schrage
Abstract
We tested the impact of insulin resistance (IR) on resting cerebral blood flow (CBF) in adults with metabolic syndrome (MetSyn). Using MRI and research pharmaceuticals to study the role of NOS, ET-1, or COX signaling, we found that adults with MetSyn exhibit substantially lower CBF that is not explained by changes in NOS or ET-1 signaling. Interestingly, adults with MetSyn show a loss of COX-mediated vasodilation in the anterior but not posterior circulation.
Topics & Concepts
Cerebral blood flowMetabolic syndromeVasodilationInternal medicineCerebral circulationMedicineEndocrinologyInsulin resistanceBlood flowBasal (medicine)CardiologyInsulinDiabetes mellitusAdvanced MRI Techniques and ApplicationsCerebrovascular and Carotid Artery DiseasesAcute Ischemic Stroke Management