Molecularly imprinted and cladded polymers for constructing a portable plasmonic immunoassay for peptides in biofluids
Zhanchen Guo, Qi Zhang, Rongrong Xing, Zhen Liu
Abstract
Using two molecularly imprinted and cladded polymers (cMIPs), an inexpensive, fast and portable plasmonic immuno-sandwich assay (PISA) was rationally developed for high-specificity and ultra-sensitive detection of C-peptide in urine. The dual cMIPs-based PISA allowed healthy individuals to be distinguished from diabetes patients and exhibited several significant merits over existing immunoassays, holding great promise in clinical diagnosis.
Topics & Concepts
ImmunoassayMolecularly imprinted polymerNanotechnologyPlasmonPolymerMaterials scienceCombinatorial chemistryChromatographyChemistryOptoelectronicsSelectivityOrganic chemistryBiologyCatalysisAntibodyImmunologyAnalytical chemistry methods developmentBiosensors and Analytical DetectionAdvanced biosensing and bioanalysis techniques