Synthesis and bioactivity investigation of benzophenone and its derivatives
Lei Chun, Wanjing Yang, Ziyu Lin, Yuyan Tao, Renping Ye, Yucai Jiang, Yuli Chen, Bei-Dou Zhou
Abstract
values of 0.48, 0.82, 0.26, and 0.99 μM, respectively. Finally, the antitumour mechanism of compound 1 was investigated through network pharmacology and molecular docking analyses, which identified 22 key genes and 21 tumour pathways. AKT1, ALB, CASP3, ESR1, GAPDH, HSP90AA1, and STAT3 were considered as potential target hub genes for compound 1. These results will enable the future development of benzophenone and its derivatives.
Topics & Concepts
BenzophenoneChemistryCombinatorial chemistryStereochemistryOrganic chemistrySynthesis and biological activityComputational Drug Discovery MethodsBioactive Compounds and Antitumor Agents