Postbiotics Enhance NK Cell Activation in Stress-Induced Mice through Gut Microbiome Regulation
Ye‐Jin Jung, Hyun‐Seok Kim, Gunn Jaygal, Hye-Rin Cho, Kyung bae Lee, In-Bong Song, Jong‐Hoon Kim, Mi‐Sun Kwak, Kyung-Ho Han, Min‐Jung Bae, Moon‐Hee Sung
Abstract
, postbiotics in pathological states) is controversial. Natural killer (NK) cells play a key role in innate and adaptive immunity. In this study, we examined NK cell activation influenced by a postbiotics mixture in response to gut microbiome modulation in stress-induced mice. In vivo activation of NK cells increased in the postbiotics mixture treatment group in accordance with Th1/Th2 expression level. Meanwhile, the Red Ginseng treatment group, a reference group, showed very little expression of NK cell activation. Moreover, the postbiotics mixture treatment group in particular changed the gut microbiome composition. Although the exact role of the postbiotics mixture in regulating the immune system of stress-induced mice remains unclear, the postbiotics mixture-induced NK cell activation might have affected gut microbiome modulation.