Mimetics of ADP-Ribosylated Histidine through Copper(I)-Catalyzed Click Chemistry
Hugo Minnee, J.G.M. Rack, Gijsbert A. van der Marel, Herman S. Overkleeft, Jeroen D. C. Codée, Ivan Ahel, Dmitri V. Filippov
Abstract
-methoxy benzyl ether. Four His*-τ-ADPr peptides were screened against a library of human ADP-ribosyl hydrolases.
Topics & Concepts
ChemistryCatalysisCopperClick chemistryHistidineCombinatorial chemistryOrganic chemistryStereochemistryEnzymeClick Chemistry and ApplicationsRNA and protein synthesis mechanismsAdenosine and Purinergic Signaling