Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression
Mahmoud AbuEid, Donna McAllister, Laura McOlash, Megan Cleland Harwig, Gang Cheng, Donovan Drouillard, Kathleen A. Boyle, Micaël Hardy, Jacek Zielonka, Bryon D. Johnson, R. Blake Hill, Balaraman Kalyanaraman, Michael B. Dwinell
Abstract
. Anti-proliferative doses of Mito-CI inhibited differentiation, viability, and the suppressive function of bone marrow-derived MDSC and increased proliferation-independent activation of T cells. These data indicate that targeted inhibition of complex I has synchronous effects that cumulatively inhibits melanoma growth and promotes immune remodeling.
Topics & Concepts
Immune systemMelanomaCancer researchTumor microenvironmentMyeloid-derived Suppressor CellCell growthT cellTumor progressionChemistryBiologyImmunologyCell biologyCancerSuppressorBiochemistryGeneticsImmune cells in cancerCancer Immunotherapy and BiomarkersFerroptosis and cancer prognosis