WIPI2 positively regulates mitophagy by promoting mitochondrial recruitment of VCP
Guang Lu, Hayden Weng Siong Tan, Tomas Schmauck‐Medina, Liming Wang, Jiaqing Chen, Yik-Lam Cho, Kelie Chen, Jingzi Zhang, Weifeng He, Yihua Wu, Dajing Xia, Jing Zhou, Evandro Fei Fang, Lei Fang, Wei Liu, Han‐Ming Shen
Abstract
ATG, autophagy related; CALCOCO2/NDP52, calcium binding and coiled-coil domain 2; CCCP, carbonyl cyanide chlorophenylhydrazone; CYCS, cytochrome c, somatic; HSPD1/HSP60, heat shock protein family D (Hsp60) member 1; IMM, inner mitochondrial membrane; MAP1LC3/LC3, microtubule associated protein 1 light chain 3; NPLOC4, NPL4 homolog, ubiquitin recognition factor; OMM, outer mitochondrial membrane; OPTN, optineurin; PtdIns3P, phosphatidylinositol-3-phosphate; PINK1, PTEN induced kinase 1; PRKN/Parkin, parkin RBR E3 ubiquitin protein ligase; UBXN6/UBXD1, UBX domain protein 6; UFD1, ubiquitin recognition factor in ER associated degradation 1; VCP/p97, valosin containing protein; WIPI2, WD repeat domain, phosphoinositide interacting 2.