The nuclear DICER–circular RNA complex drives the deregulation of the glioblastoma cell microRNAome
Agnieszka Bronisz, Arun K. Rooj, Kamil Krawczynski, Pierpaolo Peruzzi, Elżbieta Salińska, Ichiro Nakano, Benjamin Purow, E. Antonio Chiocca, Jakub Godlewski
Abstract
results in the restoration of cytosolic localization of DICER and widespread derepression of the microRNAome, leading to transcriptome-wide rearrangements that mitigate the tumorigenicity of glioblastoma cells in vitro and in vivo with correlation to favorable outcomes in patients with glioblastoma. These findings uncover the mechanistic foundation of microRNAome deregulation in malignant cells.
Topics & Concepts
microRNADicerGlioblastomaCircular RNANucleusCell biologyRNACell nucleusCellChemistryBiologyCancer researchGeneticsRNA interferenceGeneCircular RNAs in diseasesMicroRNA in disease regulationCancer-related molecular mechanisms research