Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage
Jasper Panten, Stefania Prete, James Cleland, Lauren M. Saunders, Job van Riet, Anja Schneider, Paul A. Ginno, Nina Schneider, Marie-Luise Koch, Xuqi Chen, Moritz Gerstung, Oliver Stegle, Arthur P. Arnold, James M. A. Turner, Édith Heard, Duncan T. Odom
Abstract
Abstract The Four Core Genotypes (FCG) is a mouse model system used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the Y Sry- chromosome and thus increased the expression of X-linked genes including the single-stranded RNA sensor and autoimmune disease mediator Tlr7 . This previously-unreported X-Y translocation complicates the interpretation of studies reliant on C57BL/6J FCG mice.
Topics & Concepts
Chromosomal translocationTestis determining factorBiologyGeneGeneticsChromosomeGenotypeMolecular biologyRNAY chromosomeImmune Cell Function and Interactioninterferon and immune responsesT-cell and B-cell Immunology