Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders
Gregory Hook, Thomas Reinheckel, Junjun Ni, Zhou Wu, Mark S. Kindy, Christoph Peters, Vivian Hook
Abstract
gene display improved neurobehavioral deficits, reduced neuropathology, and amelioration of neuronal cell death and inflammatory biomarkers. The significance of the compelling CTSB evidence is that the data consilience validates CTSB as a drug target for discovery of CTSB inhibitors as potential therapeutics for treating numerous neurological diseases.
Topics & Concepts
Cathepsin BNeuropathologyDownregulation and upregulationNeuroinflammationMedicineBiomarkerPathologyDiseaseBiologyGeneEnzymeBiochemistryAlzheimer's disease research and treatmentsProtease and Inhibitor MechanismsAutism Spectrum Disorder Research