Polymyxin-based photosensitizer for the potent and selective killing of Gram-negative bacteria
Muhammed Üçüncü, Bethany Mills, Sheelagh Duncan, Matteo Staderini, Kevin Dhaliwal, Mark Bradley
Abstract
The methylene blue-polymyxin conjugate demonstrated high selectivity, sensitivity and phototoxicity against Gram-negative bacteria, including in early biofilm models.
Topics & Concepts
PolymyxinPhototoxicityBacteriaPhotosensitizerGram-negative bacteriaMicrobiologyChemistryAntibioticsPolymyxin BMethylene blueConjugateBiofilmEscherichia coliIn vitroBiologyBiochemistryPhotochemistryPhotocatalysisMathematicsGeneMathematical analysisGeneticsCatalysisNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesAntibiotic Resistance in Bacteria