Aquilariperoxide A, a Sesquiterpene Dimer from Agarwood of <i>Aquilaria sinensis</i> with Dual Antitumor and Antimalarial Effects
Xiaoling Huang, Dan Cai, Peng Gao, Jigang Wang, Yong‐Xian Cheng
Abstract
Aquilariperoxide A ( 1 ), an unprecedented sesquiterpene dimer characterized by a dioxepane ring connecting two sesquiterpene units via a C–C bond, was isolated from agarwood of Aquilaria sinensis -containing resins. The structure was elucidated by spectroscopic and computational methods. A bioassay revealed that 1 significantly inhibits cell proliferation and migration in human cancer cells. The mechanism of 1 against cancer cells was briefly discussed by analysis of RNA sequence data and epithelial–mesenchymal transition. Besides, the antimalarial activity of 1 was also evaluated.
Topics & Concepts
AgarwoodSesquiterpeneTraditional medicineChemistryStereochemistryMedicinePathologyAlternative medicineWood and Agarwood ResearchIdentification and Quantification in FoodMicrobial Metabolism and Applications