Recurrent Pericarditis and Paradigm Shift in Cardiovascular Imaging and Targeted Therapeutics
Rehan Karmali, Tahir S Kafil, Aqieda Bayat, Bianca Honnekeri, Osamah Badwan, Felix Berglund, Paul Cremer, Allan L. Klein
Abstract
Recurrent pericarditis poses a significant challenge to patients and clinicians given its high morbidity and health care burden. Since the last iteration of European Society of Cardiology Guidelines in 2015, further insights have been gained into the pathophysiology, multimodality imaging assessment, and treatment of this condition. The purpose of this review is to discuss each of these aspects and highlight the role of imaging-guided therapy and interleukin-1 inhibitors in autoinflammatory phenotypes that together have transformed the care of these patients. Although future investigations are needed to optimize diagnostic surveillance and timing of therapy, recent evidence points at an encouraging paradigm shift in the treatment of recurrent pericarditis.