Signal Decoding for Glutamate Modulating Egg Laying Oppositely in Caenorhabditis elegans under Varied Environmental Conditions
Xin Wen, Yuan‐Hua Chen, Rong Li, Ming-Hai Ge, Sheng-Wu Yin, Jingjing Wu, Jiahao Huang, Hui Liu, Ping-Zhou Wang, Einav Gross, Zheng‐Xing Wu
Abstract
stimulation, ASHs and ADLs may release a large amount of glutamate and inhibit Amphid interneuron (AIA) interneurons via low-sensitivity Glutamate-gated chloride channel (GLC)-3 receptor, thus removing the inhibitory roles of AIAs on HSN activity and egg laying. However, directly measuring the amount of glutamate released by sensory neurons under different conditions and assaying the binding kinetics of receptors with the neurotransmitter are still required to support this study directly.
Topics & Concepts
Glutamate receptorCaenorhabditis elegansBiologySensory systemNeurotransmitterInhibitory postsynaptic potentialNeuronNeuroscienceReceptorSensory neuronStimulationCell biologyBiochemistryGeneGenetics, Aging, and Longevity in Model OrganismsCircadian rhythm and melatoninNeuroendocrine regulation and behavior