CCL14 is a prognostic biomarker and correlates with immune infiltrates in hepatocellular carcinoma
Yurong Gu, Xiangyong Li, Yanhua Bi, Yubao Zheng, Jialiang Wang, Xiaoyan Li, Zexuan Huang, Lubiao Chen, Yanlin Huang, Yuehua Huang
Abstract
T cells, macrophages, neutrophils, and dendritic cells. CCL14 expression in HCC negatively correlated with expression of several immune cell markers, including exhausted T cell markers, PD-1, TIM-3 and CTLA-4, suggesting its role in regulating tumor immunity. These findings demonstrate that CCL14 is a potential prognostic biomarker that determines cancer progression and correlated with tumor immune cells infiltration in HCC.
Topics & Concepts
Hepatocellular carcinomaBiomarkerImmune systemMedicineOncologyInternal medicineImmunologyBiologyBiochemistryChemokine receptors and signalingCancer Immunotherapy and BiomarkersImmune cells in cancer