Near-infrared AIE-active phosphorescent iridium(<scp>iii</scp>) complex for mitochondria-targeted photodynamic therapy
Zhengyin Pan, Bin-Fa Liang, Yun-Shi Zhi, Dahong Yao, Chenyang Li, Haiqiang Wu, Liang He
Abstract
has been further demonstrated in tumour-bearing mice. Together, the results suggest that Ir1 is a promising photosensitizer for mitochondria-targeted imaging and cancer phototherapy.
Topics & Concepts
Photodynamic therapyPhototoxicityColocalizationPhotosensitizerMitochondrionSinglet oxygenPhosphorescenceCancer cellReactive oxygen speciesChemistryApoptosisCancer researchIridiumIn vivoEndoplasmic reticulumCancerBiophysicsFluorescencePhotochemistryCell biologyIn vitroBiologyBiochemistryMedicineOxygenInternal medicinePhysicsBiotechnologyQuantum mechanicsOrganic chemistryCatalysisNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesLuminescence and Fluorescent Materials