Design, synthesis and biological evaluation of novel coumarin derivatives as multifunctional ligands for the treatment of Alzheimer's disease
Wenjie Liu, Limeng Wu, Wenwu Liu, Liting Tian, Huanhua Chen, Zhongchan Wu, Nan Wang, Xin Liu, Jingsong Qiu, Xiangling Feng, Zihua Xu, Xiaowen Jiang, Qingchun Zhao
Topics & Concepts
ChemistryCoumarinCytotoxicityADMECholinesteraseAcetylcholinesterasePharmacologyIC50AchéLead compoundBlood–brain barrierButyrylcholinesteraseStereochemistryCombinatorial chemistryIn vitroEnzymeBiochemistryOrganic chemistryCentral nervous systemMedicineNeuroscienceBiologyCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsAlzheimer's disease research and treatments