Extremely drug-resistant NDM-9-producing ST147 Klebsiella pneumoniae causing infections in Italy, May 2020
Marco Falcone, Cesira Giordano, Simona Barnini, Giusy Tiseo, Alessandro Leonildi, P Malacarne, Francesco Menichetti, Alessandra Carattoli
Abstract
A large outbreak of New Delhi metallo-beta-lactamase (NDM)-1-producing Klebsiella pneumoniae sequence type (ST) 147 occurred in Tuscany, Italy in 2018–2019. In 2020, ST147 NDM-9-producing K. pneumoniae were detected at the University Hospital of Pisa, Tuscany, in two critically ill patients; one developed bacteraemia. Genomic and phylogenetic analyses suggest relatedness of 2018–2019 and 2020 strains, with a change from NDM-1 to NDM-9 in the latter and evolution by colistin, tigecycline and fosfomycin resistance acquisition.
Topics & Concepts
TigecyclineKlebsiella pneumoniaeFosfomycinColistinMicrobiologyDrug resistanceMultilocus sequence typingOutbreakBiologyVirologyMedicineAntibioticsEscherichia coliGenotypeGeneticsGeneAntibiotic Resistance in BacteriaEnterobacteriaceae and Cronobacter ResearchUrinary Tract Infections Management