Oxidative trimerization of indoles <i>via</i> water-assisted visible-light photoredox catalysis and the study of their anti-cancer activities
Liting Cheng, Sheng-Qi Luo, Bor‐Cherng Hong, Chia‐Ling Chen, Wen‐Shan Li, Gene‐Hsiang Lee
Abstract
Incorporation of water has been revealed to successfully facilitate visible-light photoredox catalysis of indole leading to increased production of C2-quaternary indolinone. The water-promoted photoreaction of indole under catalyst-free conditions by a household compact fluorescence light was also demonstrated. The antiproliferative activity of the synthesized indolinones was evaluated against three human cancer cell lines.
Topics & Concepts
ChemistryIndole testCatalysisVisible spectrumFluorescencePhotoredox catalysisPhotochemistryOxidative phosphorylationCombinatorial chemistryPhotocatalysisOrganic chemistryBiochemistryOptoelectronicsPhysicsQuantum mechanicsSynthesis of Indole DerivativesCatalytic C–H Functionalization MethodsRadical Photochemical Reactions