Dysregulation of USP18/FTO/PYCR1 signaling network promotes bladder cancer development and progression
Wei Song, Ke Yang, Jianjun Luo, Zhiyong Gao, Yunliang Gao
Abstract
transcript to promote bladder cancer initiation and progression. Our work shows the importance of N6-methyladenosine RNA modification in bladder cancer development, and highlights UPS18/FTO/PYCR1 signaling network as potential therapeutic targets of bladder cancer.
Topics & Concepts
DemethylaseN6-MethyladenosineMethylationBladder cancerRNA methylationMethyltransferaseCancer researchCarcinogenesisCancerEpigeneticsRNADNA methylationBiologyChemistryCell biologyGeneBiochemistryGeneticsGene expressionRNA modifications and cancerCancer-related gene regulationEpigenetics and DNA Methylation