Back Cover: Glutathione Depletion‐Induced Activation of Dimersomes for Potentiating the Ferroptosis and Immunotherapy of “Cold” Tumor (Angew. Chem. Int. Ed. 22/2022)
Zhanwei Zhou, Huan Liang, Ruoxi Yang, Ying Yang, Jingwen Dong, Yongxiang Di, Minjie Sun
Abstract
Glutathione (GSH) is abundant in “cold” tumors and adversely affects ferroptosis therapy and immune response. In their Research Article (DOI: 10.1002/anie.202202843), Minjie Sun and co-workers developed cinnamaldehyde dimer-based vesicles (CDC dimersomes) capable of depleting intracellular GSH via Michael addition to potentiate the ferroptosis and immunotherapy of breast cancer by turning the “cold” tumor “hot”. CDC is the first drug dimer-based vesicle applied for immune activation, inspiring the future design of functional vesicles.
Topics & Concepts
GlutathioneChemistryImmune systemImmunotherapyIntracellularCancer researchVesicleCell biologyBiochemistryImmunologyBiologyMembraneEnzymeSulfur Compounds in BiologyNanoplatforms for cancer theranosticsFerroptosis and cancer prognosis