Vascular Endothelial Growth Factor A Contributes to Increased Mammalian Respiratory Epithelial Permeability Induced by Pasteurella multocida Infection
Lin Lin, Jie Yang, Dajun Zhang, Qingjie Lv, Fei Wang, Peng Liu, Mixue Wang, Congcong Shi, Xi Huang, Wan Liang, Chen Tan, Xiangru Wang, Huanchun Chen, Brenda A. Wilson, Bin Wu, Zhong Peng
Abstract
The mammalian respiratory epithelium forms the first line of defense against infections with P. multocida , an important zoonotic respiratory pathogen. In this study, we found that P. multocida infection increased respiratory epithelial permeability and promoted the induction of the HIF-1α–VEGFA axis in both mouse and murine cell models.
Topics & Concepts
Pasteurella multocidaAdherens junctionBiologyImmunologyVascular permeabilityTight junctionMicrobiologyCell biologyCadherinEndocrinologyCellBacteriaGeneticsMicrobial infections and disease researchAquaculture disease management and microbiotaNeuroscience of respiration and sleep