A Novel Cyclic Mobile Transporter Can Induce Apoptosis by Facilitating Chloride Anion Transport into Cells
Goutam Kulsi, Achinta Sannigrahi, Snehasis Mishra, Krishna Das Saha, Sriparna Datta, Partha Chattopadhyay, Krishnananda Chattopadhyay
Abstract
ion transport. The macrocycle induced cytochrome c leakage and changes in mitochondrial membrane potential along with activation of family of caspases, suggesting that the cellular apoptosis occurs through a caspase-dependent intrinsic pathway. The present results suggest the possibility of using the macrocycle as a biological tool of high therapeutic value.
Topics & Concepts
ChemistryAntiporterAmideStereochemistryCytochrome cMembraneCombinatorial chemistryApoptosisBiochemistryChemical Synthesis and AnalysisClick Chemistry and ApplicationsDNA and Nucleic Acid Chemistry