Nickel-Catalyzed Alkylation of Oxindoles with Secondary Alcohols
Atanu Bera, Adrija Ghosh, Debasis Banerjee
Abstract
Herein, we have demonstrated a simple nickel-catalyzed C-3-selective alkylation of 2-oxindoles using a wide variety of secondary alkyl alcohols. As a special highlight, functionalization of the cholesterol derivative was reported. Control experiments, initial mechanistic studies, and deuterium-labeling experiments were performed for the alkylation process.
Topics & Concepts
AlkylationNickelCatalysisChemistryAlkylDerivative (finance)Organic chemistryCombinatorial chemistryEconomicsFinancial economicsAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization MethodsAsymmetric Synthesis and Catalysis