Pragmatic cluster randomized trial to evaluate effectiveness and implementation of EHR-facilitated collaborative symptom control in cancer (E2C2): addendum
Jeph Herrin, Lila J. Finney Rutten, Kathryn J. Ruddy, Kurt Kroenke, Andrea Cheville
Abstract
We previously described the hypotheses, outcomes, design, and analysis for E2C2, a pragmatic stepped-wedge trial to assess an intervention to improve symptom control in patients with cancer. Subsequent consideration of the design and cohort led to the addition of a second primary hypothesis. This article describes and presents the rationale for this second hypothesis. This addendum also details a revised analytic approach, necessitated by inconsistencies in the original analytic plan. The design, outcomes, and other aspects of the protocol remain unchanged.
Topics & Concepts
AddendumMedicineRandomized controlled trialProtocol (science)Research designAlternative medicineMedical physicsPathologyStatisticsLawMathematicsPolitical scienceCancer survivorship and careBRCA gene mutations in cancerChildhood Cancer Survivors' Quality of Life