Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT)
Dennis C. Koester, Vanessa M. Marx, Sarah Williams, Jan Jiřiček, Maxime Dauphinais, Olivier René, Sarah L. Miller, Lei Zhang, Debjani Patra, Yen‐Liang Chen, H. W. K. Cheung, Jonathan E. Gable, Suresh B. Lakshminarayana, Colin Osborne, Jean-René Galarneau, Upendra Kulkarni, Wendy Richmond, Angela Bretz, Linda Xiao, František Supek, Christian Wiesmann, Honnappa Srinivas, C. Be, Pascal Mäser, Marcel Kaiser, Ryan Ritchie, Michael P. Barrett, Thierry T. Diagana, Christopher R. Sarko, Srinivasa P. S. Rao
Abstract
) to cure a CNS disease such as HAT.
Topics & Concepts
African trypanosomiasisIn vivoTrypanosomiasisIn silicoTrypanosoma bruceiChemistryTrypanosomaPharmacologyParasite hostingChagas diseaseDrug discoveryPenetrant (biochemical)In vitroProteasomeImmunologyVirologyBiologyBiochemistryGeneticsComputer scienceOrganic chemistryWorld Wide WebGeneTrypanosoma species research and implicationsBiochemical and Molecular ResearchHIV/AIDS drug development and treatment