Litcius/Paper detail

Structural basis for NaV1.7 inhibition by pore blockers

Jiangtao Zhang, Yiqiang Shi, Zhuo Huang, Yue Li, Bei Yang, Jianke Gong, Daohua Jiang

2022Nature Structural & Molecular Biology35 citationsDOI

Topics & Concepts

Helix (gastropod)ChemistryBiophysicsConformational changeNav1.5Sodium channelChannel blockerGatingProtein structureCrystallographyStereochemistryBiochemistrySodiumBiologyCalciumOrganic chemistryEcologySnailIon channel regulation and functionNeuroscience and Neuropharmacology ResearchCardiac electrophysiology and arrhythmias