Arsenic activated GLUT1-mTORC1/HIF-1α-PKM2 positive feedback networks promote proliferation and migration of bladder epithelial cells
Zhushan Fu, Meiqi Deng, Qing Zhou, Sihao Li, Weijue Liu, Siyan Cao, Lei Zhang, Yu Hang Deng, Shuhua Xi
Topics & Concepts
mTORC1ArsenitePKM2GLUT1Anaerobic glycolysisCancer researchCarcinogenesisGlycolysisChemistryWarburg effectBiologyCell biologyCell growthGlucose transporterBiochemistryPyruvate kinaseSignal transductionPI3K/AKT/mTOR pathwayMetabolismArsenicEndocrinologyOrganic chemistryInsulinGeneCancer, Hypoxia, and MetabolismSulfur Compounds in BiologyCancer, Lipids, and Metabolism