Solvent-free base-controlled addition reaction of<i>H</i>-phosphonates and<i>H</i>-phosphine oxides to α-CF<sub>3</sub>styrenes: facile synthesis of β-CF<sub>3</sub>-substituted phosphonates and phosphine oxides
Qianding Zeng, Ying Liu, Jingjing He, Yupian Deng, Pai Zheng, Zhudi Sun, Song Cao
Abstract
-phosphine oxides, respectively, was developed. The reaction proceeded smoothly within 2 h at room temperature without the cleavage of the rather fragile C-F bond in α-(trifluoromethyl)styrenes and afforded a wide variety of structurally diverse and valuable β-trifluoromethyl-containing phosphonates and phosphine oxides in moderate to good yields. This protocol features mild conditions, wide substrate scope, simple manipulation, and excellent functional group compatibility.
Topics & Concepts
ChemistryPhosphineSolventBase (topology)Polymer chemistryMedicinal chemistryOrganic chemistryCatalysisMathematical analysisMathematicsFluorine in Organic ChemistryCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions