Large-Scale G Protein-Coupled Olfactory Receptor–Ligand Pairing
Xiaojing Cong, Wenwen Ren, Jody Pacalon, Rui Xu, Lun Xu, Xuewen Li, Claire A. de March, Hiroaki Matsunami, Hongmeng Yu, Yiqun Yu, Jérôme Golebiowski
Abstract
functional assays of 111 ORs and 7 odorants of distinct scaffolds. Sixty-four new OR-odorant pairs were discovered, and 25 ORs were deorphanized here. The best model demonstrated a 56% deorphanization rate. The PCM-RF approach will accelerate OR-odorant mapping and OR deorphanization.
Topics & Concepts
G protein-coupled receptorLigand (biochemistry)Computational biologyMutagenesisReceptorOlfactory receptorOlfactionChemistryBiologyBiophysicsBiochemistryNeuroscienceGeneMutantReceptor Mechanisms and SignalingOlfactory and Sensory Function StudiesComputational Drug Discovery Methods